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Light Chain Crystalline Proximal Tubulopathy and Podocytopathy With Staining for Both Light and Heavy Chain
Seoyoung Choi1,2, Kyung Chul Moon1,2,3
1Department of Pathology, Seoul National University Hospital, Seoul, Korea.
Abstract:
A 69-year-old male patient presented with weight loss and proteinuria. His medical history included papillary thyroid carcinoma. Laboratory findings showed proteinuria and high κ light chain levels in both urine and serum. Bone marrow aspiration revealed plasma cell myeloma of the IgA-κ type. Kidney biopsy revealed crystal inclusions in multiple locations, including podocytes and proximal tubular epithelial cells. Immunofluorescence and immunohistochemistry revealed positive staining for κ light chain and IgA. The patient was diagnosed with light chain crystalline podocytopathy and proximal tubulopathy. Our case presented some peculiarities: positive staining for heavy-chain IgA in addition to κ light chain and the absence of concurrent Fanconi syndrome or focal segmental glomerulosclerosis.
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