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Cushing's Disease Presented by Reversible Dilated Cardiomyopathy

Berna İmge Aydoğan1, Demet Menekşe Gerede2, Asena Gökçay Canpolat1

  • 1Department of Endocrinology and Metabolism, Ankara University Faculty of Medicine, 06410 Ankara, Turkey.

Case Reports in Cardiology
|December 10, 2015
PubMed

Insights

Cushing's syndrome can cause reversible dilated cardiomyopathy, even without hypertension or hypertrophy. Successful surgery for pituitary microadenoma led to full recovery of heart function in a patient.

Area of Science:

  • Endocrinology
  • Cardiology

Background:

  • Dilated cardiomyopathy is infrequently associated with Cushing's syndrome.
  • This association is even rarer in cases lacking hypertension and left ventricular hypertrophy.

Purpose of the Study:

  • To report a case of Cushing's syndrome presenting with dilated cardiomyopathy.
  • To highlight Cushing's syndrome as a reversible cause of dilated cardiomyopathy.

Main Methods:

  • A case report of a 48-year-old female patient with Cushing's syndrome.
  • Diagnosis involved clinical presentation, echocardiography, and pituitary MRI.
  • Treatment included diuretics, ketoconazole, and transsphenoidal adenomectomy.

Main Results:

  • The patient presented with severe proximal myopathy and dilated cardiomyopathy without ventricular hypertrophy.
  • Pituitary MRI confirmed a microadenoma.
  • Post-surgery, the patient experienced full recovery of symptoms and echocardiographic findings within six months.

Conclusions:

  • Cushing's syndrome should be considered a potential reversible cause of dilated cardiomyopathy.
  • Surgical treatment of the underlying cause can restore cardiac function.

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