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Hemostatic defects in dengue hemorrhagic fever
1Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Reviews of Infectious Diseases
|May 1, 1989
Summary
Dengue hemorrhagic fever presents with fever followed by bleeding. Dengue shock syndrome may cause hypovolemic shock, with dysfunction possibly due to biologic mediators.
Area of Science:
- Medical Science
- Virology
- Pathology
Background:
- Dengue hemorrhagic fever (DHF) is a severe mosquito-borne viral illness.
- DHF is characterized by fever, hemorrhagic manifestations, and potential hypovolemic shock (dengue shock syndrome).
- Pathological changes occur in the liver, reticuloendothelial, and vascular systems.
Purpose of the Study:
- To describe the clinical and pathological characteristics of Dengue Hemorrhagic Fever.
- To elucidate the underlying mechanisms of DHF and Dengue Shock Syndrome.
Main Methods:
- Clinical observation of patients with Dengue Hemorrhagic Fever.
- Pathological examination of affected organs.
- Analysis of physiological changes during the course of the illness.
Main Results:
- Sudden onset fever (2-7 days) followed by hemorrhagic manifestations.
- Significant hepatic, reticuloendothelial, and vascular system changes, including liver cell necrosis and erythrocyte diapedesis.
- Physiological dysfunction is proposed to result from biologic mediators rather than extensive structural damage.
Conclusions:
- Dengue Hemorrhagic Fever involves significant systemic physiological dysfunction.
- The rapid recovery of survivors suggests a reversible process, likely mediated by biologic factors.
- Understanding these mediators is crucial for managing Dengue Hemorrhagic Fever and Dengue Shock Syndrome.