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Related Experiment Video

Updated: Mar 29, 2026

Digital Microfluidics for Automated Proteomic Processing
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Digital Microfluidics: A New Paradigm for Radiochemistry.

Pei Yuin Keng, R Michael van Dam

    Molecular Imaging
    |December 10, 2015
    PubMed
    Summary

    Digital microfluidics enables microliter-scale radiochemistry for producing high-specific-activity (SA) positron emission tomography (PET) tracers. This compact technology reduces costs and may eliminate the need for hot cells in routine tracer synthesis.

    Area of Science:

    • Radiochemistry
    • Microfluidics
    • Nuclear Medicine

    Background:

    • Digital microfluidics offers precise control of reagents at the microliter scale.
    • Traditional radiochemistry methods can be costly and yield lower specific activity (SA).
    • Positron emission tomography (PET) requires high-SA tracers for sensitive imaging.

    Purpose of the Study:

    • To review the advancements in digital microfluidics for radiochemistry.
    • To explore the application of this technology in synthesizing PET tracers.
    • To highlight the potential for routine production of high-SA tracers.

    Main Methods:

    • Utilizing digital microfluidics for precise electronic control of reagent droplets.
    • Performing radiochemistry at the microliter scale.

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  • Exploring synthesis strategies like isotopic exchange for enhanced SA.

    • Main Results:

    • Digital microfluidics enables radiochemistry at the microliter scale, reducing reagent costs.
    • The technology improves specific activity (SA) by minimizing stable isotope contamination.
    • Compact, flexible, and reliable synthesis systems are achievable with single-chip designs.

    Conclusions:

    • Digital microfluidics presents a practical approach for routine high-SA PET tracer production.
    • This technology could enable self-shielded synthesizers, potentially removing the need for hot cells.
    • Advancements in digital microfluidics are poised to impact neuroimaging and other PET applications.