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Sex- and Age-Specific Reference Values and Cutoff Points for TPOAb: Tehran Thyroid Study.
Atieh Amouzegar1, Mahmood Bakhtiyari1,2, Mohammad Ali Mansournia2
11 Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences , Tehran, Iran .
Thyroid : Official Journal of the American Thyroid Association
|December 10, 2015
Summary
This study establishes new reference intervals for thyroid peroxidase antibodies (TPOAb) and identifies optimal cutoff points for hypothyroidism in an iodine-sufficient population. These findings aim to improve diagnostic accuracy for thyroid disorders.
Area of Science:
- Endocrinology
- Clinical Chemistry
- Immunology
Background:
- Established guidelines for thyroid peroxidase antibodies (TPOAb) reference intervals face controversy.
- Accurate TPOAb reference intervals are crucial for diagnosing thyroid dysfunction.
Purpose of the Study:
- Determine TPOAb reference intervals across different age and sex groups.
- Establish TPOAb cutoff points for predicting subclinical and overt hypothyroidism.
- Provide updated diagnostic criteria for an iodine-sufficient population.
Main Methods:
- Cross-sectional study within the Tehran Thyroid Study (TTS).
- Followed 4174 healthy euthyroid individuals for 10 years.
- Assessed thyroid function tests and TPOAb levels.
Main Results:
- Estimated TPOAb reference intervals: 1.5-32.8 IU/mL (males) and 2.1-35 IU/mL (females).
- No significant age-related variations observed in either sex.
- Optimal TPOAb cutoff points: 18.38 IU/mL (clinical hypothyroidism) and 14.77 IU/mL (subclinical hypothyroidism).
Conclusions:
- Successfully established TPOAb reference intervals for an iodine-sufficient population.
- Defined optimal TPOAb cutoff points for hypothyroidism prediction.
- Provides valuable data for clinical practice and thyroid disorder diagnosis.
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