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Stratified epithelium consists of several stacked layers of cells. They provide the durability to withstand constant physical and chemical attacks. Stratified epithelium is named after the shape of the most apical layer of cells. Stratified squamous epithelium is the most common type found in the human body. In this tissue, the apical cells are squamous, whereas the basal layer contains either columnar or cuboidal cells. The basal cells divide to form new daughter cells, which gradually become...
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The vulva encompasses the external structures of the female reproductive system. At the forefront is the monpubis, a cushion of fatty tissue atop the pubic bone. Once puberty sets in, this area typically grows hair. Extending from just behind the mons pubis are the labia majora (labia = 'lips'; majora = 'larger'), which are larger skin fs olds coated with hair. Nestled within are the labia minora (labia = 'lips'; minora = 'smaller'), which are thinner, more...
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Updated: Mar 29, 2026

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Epithelial vulvar neoplasms and their changing classification.

Russell Ball1, Katherine M Ball2, Jason Reutter3

  • 1Ball DermPath, Greensboro, North Carolina, USA.

Seminars in Cutaneous Medicine and Surgery
|December 10, 2015
PubMed
Summary
This summary is machine-generated.

Recent advances in understanding vulvar squamous lesions have led to classification changes. This summary clarifies terminology for HPV and non-HPV precursor lesions, including dermatoses like lichen sclerosus.

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Area of Science:

  • Gynecologic Pathology
  • Dermatopathology
  • Oncology

Background:

  • Vulvar squamous lesion classification has evolved significantly.
  • New scientific data has refined diagnostic terminology.
  • Understanding precursor lesions is crucial for patient management.

Purpose of the Study:

  • To summarize changes in the classification scheme for squamous lesions of the vulva.
  • To clarify the distinction between human papillomavirus (HPV)-related and non-HPV precursor lesions.
  • To aid clinicians and pathologists in understanding current and historical terminology.

Main Methods:

  • Review of recent scientific literature on vulvar squamous lesions.
  • Analysis of diagnostic terminology changes over the past 75 years.
  • Categorization of precursor lesions into HPV and non-HPV types.

Main Results:

  • Precancerous and cancerous vulvar lesions arise from various preconditions.
  • Non-HPV precursor lesions include dermatoses such as lichen sclerosus and lichen planus.
  • HPV on non-mucosal sites has different malignant potential compared to genital sites.

Conclusions:

  • The classification of vulvar squamous lesions is dynamic due to ongoing research.
  • Awareness of terminology shifts is essential to prevent diagnostic confusion.
  • This summary provides key insights for healthcare professionals managing these conditions.