Related Experiment Video
Updated: Mar 29, 2026

In Vitro and In Vivo Evaluation of Photocontrolled Biologically Active Compounds - Potential Drug Candidates for Cancer Photopharmacology
Published on: September 29, 2023
Evaluation of Different Light Conditions in the Working Environment for Handling Photosensitive and Thermolabile
Tania Hernandez Duran1, Neel Ravela, Sandra Sanchez Rivero
1Avant Santé Research Centre S.A. de C.V., Bioanalytical Department, San Pedro Garza García, Nuevo León, México.
Abstract:
Lighting in the working environment plays a significant role on the degree of degradation of photosensitive, thermolabile compounds and on working efficiency. Light emitting diodes (LEDs) are semiconductor light emitting devices that are promising artificial light sources with easy modulation of light wave signals and are also known for low heat generation. Therefore, the effect of polychromatic LED light was tested in the working environment using the drug compounds montelukast, nifedipine, and clavulanic acid, which are known to be photosensitive or thermolabile. As a control, other lighting sources like a sodium lamp, a classic (incandescent, tungsten) lamp, and indirect sunlight were also used in this study. All the experiments were carried out with methanolic solutions at room temperature. An Acquity UPLC/MS/MS system was used for quantification of the main analytes and degradation products. Under the tested conditions, LED lighting proved to be more suitable for handling photosensitive and thermolabile compounds.
More Related Videos
05:13LED-Based In Vitro Screening for Assessing Photoactivable Molecules in Bacterial Photodynamic Inactivation
Published on: January 24, 2025
08:16Method for the Assessment of Effects of a Range of Wavelengths and Intensities of Red/near-infrared Light Therapy on Oxidative Stress In Vitro
Published on: March 21, 2015
Related Concept Videos
Photoluminescence: Applications
Variables Affecting Phosphorescence and Fluorescence
Photoreceptors and Plant Responses to Light
Photoreceptors and Visual Pathways