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Updated: Mar 29, 2026

Metal-free Synthesis of Ynones from Acyl Chlorides and Potassium Alkynyltrifluoroborate Salts
Published on: February 24, 2015
Amination-Oxidation Strategy for the Copper-Catalyzed Synthesis of Monoarylamines
Christopher Thomas1, Marvin Wu1, Kelvin L Billingsley1
1Department of Chemistry and Biochemistry, San Francisco State University , San Francisco, California 94132, United States.
Abstract:
A novel approach for the synthesis of monoarylamines from aryl halides is presented. This method employs an inexpensive, nontoxic metal source (copper) and incorporates a stable ammonia surrogate (α-amino acids), obviating the need for special experimental setup or handling of ammonia reagents. This process, which is proposed to proceed via an amination-oxidation sequence, selectively promotes the transformation of a range of aryl and heteroaryl iodides as well as bromides to the corresponding monoarylamines.
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