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Removing a retained placenta by oxytocin--a controlled study.
C Wilken-Jensen1, V Strøm, M D Nielsen
1Department of Gynecology and Obstetrics, Glostrup University Hospital, Gentofte, Denmark.
American Journal of Obstetrics and Gynecology
|July 1, 1989
Summary
Umbilical vein oxytocin administration did not increase maternal plasma levels but significantly accelerated placental delivery. This finding suggests a localized effect on the uterus, impacting postpartum care.
Area of Science:
- Obstetrics and Gynecology
- Pharmacology
- Reproductive Medicine
Background:
- Oxytocin is a key hormone in labor and postpartum care.
- Investigating novel routes of oxytocin administration is crucial for optimizing obstetric interventions.
- Umbilical vein administration offers a direct route to the uterus post-delivery.
Purpose of the Study:
- To evaluate the effect of umbilical vein oxytocin on maternal plasma oxytocin concentrations.
- To determine if umbilical vein oxytocin accelerates placental delivery.
- To assess the efficacy of direct umbilical vein oxytocin administration.
Main Methods:
- A placebo-controlled study involving 40 women immediately after delivery.
- Administration of 100 IU oxytocin or placebo into the umbilical vein.
- Measurement of maternal plasma oxytocin concentrations and time to placental delivery.
Main Results:
- No significant increase in maternal plasma oxytocin was observed after umbilical vein administration.
- Placental delivery was significantly accelerated in the oxytocin group (12 minutes) compared to placebo (40 minutes).
- The difference in placental delivery time was statistically significant (p < 0.05).
Conclusions:
- Umbilical vein oxytocin administration does not lead to systemic absorption detectable in maternal plasma.
- Direct umbilical vein oxytocin effectively accelerates the third stage of labor, facilitating faster placental delivery.
- This route may offer a localized therapeutic option for managing postpartum hemorrhage and retained placenta.