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Serum 25-OH Vitamin D Level in Psoriatic Patients and Comparison With Control Subjects
Masoud Maleki1, Yalda Nahidi2, Sahar Azizahari1
1Cutaneous Leishmaniasis Research Centre, Department of Dermatology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Background:
Vitamin D has been shown to have immunomodulatory effects, and previous studies have proposed a role of vitamin D deficiency in multiple autoimmune diseases, including psoriasis.
Objectives:
The aim of this study was to investigate serum vitamin D levels in psoriatic patients and compare them with levels in controls.
Methods:
This study was carried out in 50 psoriasis patients. Serum vitamin D was measured by enzyme-linked immunosorbent assay.
Results:
The mean serum vitamin D levels in psoriatic patients and controls were 14.92 ± 6.31 and 12.52 ± 4.54 ng/mL, respectively. The difference was not statistically significant (P = .06). The prevalence of vitamin D deficiency (<20 ng/mL) was 84.0% in psoriatic patients and 93.0% in controls (P = .21).
Conclusions:
Most of the patients with psoriasis had vitamin D deficiency, which may have contributed to the evolution of their psoriasis. However, considering the high prevalence of vitamin D deficiency in Iran, no difference was noted between the psoriatic patients and the controls.
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