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Updated: Mar 28, 2026
Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Ocular Surface Squamous Neoplasia in a Living-Related Conjunctival Limbal Allograft
Kevin J Shah1, Gautham Mogilishetty, Edward J Holland
1*Department of Ophthalmology, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH; †Department of Medicine, Renal Transplant Division, University of Cincinnati, Cincinnati, OH; and ‡Department of Ophthalmology, Cincinnati Eye Institute/University of Cincinnati, Cincinnati, OH.
Purpose:
To report a single case of ocular surface squamous neoplasia (OSSN) that occurred in a living-related conjunctival limbal allograft (lr-CLAL).
Methods:
Case report and literature review.
Results:
A 70-year-old white man developed OSSN in a histocompatible identical lr-CLAL over 3 years after the surgical procedure. Incisional biopsy was performed, and topical interferon alpha-2b was initiated. Pathology results confirmed carcinoma in situ. After modest results with topical interferon alpha-2b, the patient was treated with excisional biopsy with mitomycin-C (0.04 mg/mL) and cryotherapy. Simultaneously, the lr-CLAL was replaced with a keratolimbal allograft of a deceased donor. The patient maintained 20/25 best-corrected visual acuity at last follow-up.
Conclusions:
We present an unusual case of primary OSSN in a recipient of an lr-CLAL that was clinically confined to the borders of the graft.
