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Pathogenesis and pathology of graft-vs.-host disease
J E Wagner1, G B Vogelsang, W E Beschorner
1Department of Oncology and Pediatrics, Johns Hopkins Oncology Center, Johns Hopkins University, Baltimore, MD 21205.
The American Journal of Pediatric Hematology/Oncology
|January 1, 1989
Abstract:
Over the past decade, there has been a significant increase in the number of patients with a variety of malignant and nonmalignant disorders referred for bone marrow transplantation. Despite numerous advances in the care of such patients after allogeneic bone marrow transplantation, acute and chronic graft-vs.-host disease continues to be a principal cause of morbidity and mortality. In this article, we will present an overview of the pathogenesis, clinical presentation, and pathological manifestations of these two major complications.