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NCCN Guidelines Insights Breast Cancer, Version 1.2016
William J Gradishar1, Benjamin O Anderson1, Ron Balassanian1
1From Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Washington/Seattle Cancer Care Alliance; UCSF Helen Diller Family Comprehensive Cancer Center; UC San Diego Moores Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; University of Alabama at Birmingham Comprehensive Cancer Center; The University of Texas MD Anderson Cancer Center; Mayo Clinic Cancer Center; Fox Chase Cancer Center; Memorial Sloan Kettering Cancer Center; Massachusetts General Hospital Cancer Center; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; University of Michigan Comprehensive Cancer Center; Fred & Pamela Buffett Cancer Center; Roswell Park Cancer Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Research Advocacy Network; Moffitt Cancer Center; City of Hope Comprehensive Cancer Center; Stanford Cancer Institute; Huntsman Cancer Institute at the University of Utah; and National Comprehensive Cancer Network.
The National Comprehensive Cancer Network (NCCN) updated its 2016 breast cancer guidelines with new preoperative systemic therapy principles. Recommendations for hormone receptor-positive and HER2-positive metastatic breast cancer were also revised based on recent evidence.
Area of Science:
- Oncology
- Clinical Practice Guidelines
Background:
- The National Comprehensive Cancer Network (NCCN) provides evidence-based guidelines for cancer treatment.
- Regular updates are crucial to incorporate new research and improve patient care.
Purpose of the Study:
- To summarize key updates to the 2016 NCCN Guidelines for Breast Cancer, focusing on systemic therapy.
- To highlight new recommendations for preoperative systemic therapy.
- To detail revised systemic therapy strategies for specific breast cancer subtypes.
Main Methods:
- Review of the 2016 NCCN Guidelines for Breast Cancer.
- Analysis of newly incorporated evidence and expert panel discussions.
- Synthesis of updated recommendations for systemic therapy.
Main Results:
- Introduction of a new section on principles of preoperative systemic therapy.
- Updated systemic therapy recommendations for hormone receptor-positive breast cancer (adjuvant and metastatic settings).
- Revised systemic therapy recommendations for HER2-positive metastatic breast cancer.
Conclusions:
- The 2016 NCCN Guidelines for Breast Cancer incorporate significant updates to systemic therapy.
- These revisions reflect new evidence and aim to optimize treatment for various breast cancer types.
- The guidelines provide essential information for clinicians managing breast cancer patients.
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