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Related Concept Videos

Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

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Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
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Chronic Obstructive Pulmonary Disease01:24

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COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
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COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

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Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
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COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

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Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
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Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

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Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
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Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

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Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
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Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD
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[COPD: An early disease].

V Margelidon-Cozzolino1, K Chbini2, N Freymond3

  • 1Service de pneumologie A, centre hospitalier de Lyon Sud, hospices civils de Lyon, faculté de médecine, université Claude-Bernard Lyon 1, 69310 Pierre-Bénite, France.

Revue De Pneumologie Clinique
|December 15, 2015
PubMed
Summary
This summary is machine-generated.

Genetic factors in Chronic Obstructive Pulmonary Disease (COPD) involve cellular and biochemical mechanisms in bronchial inflammation. Understanding these genetic targets offers new diagnostic markers and potential drug targets for COPD.

Keywords:
BPCOCOPDGeneticGénétiqueMicro-ARNsMicroRNAMicrobiomeOxydative stressStress oxydatifToll-like receptor

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Area of Science:

  • Pulmonary Medicine
  • Genetics
  • Biochemistry

Background:

  • Chronic Obstructive Pulmonary Disease (COPD) pathogenesis involves complex cellular and biochemical pathways in bronchial inflammation.
  • Oxidative stress and the lung microbiome are increasingly recognized as critical factors in COPD development.
  • Genetic predisposition plays a significant role in the susceptibility and progression of COPD.

Purpose of the Study:

  • To review the underlying genetic mechanisms contributing to COPD.
  • To explore the interplay between genetic factors, oxidative stress, and the lung microbiome in COPD.
  • To identify potential genetic targets for novel therapeutic strategies and diagnostic markers.

Main Methods:

  • Review of existing literature on COPD genetics, pathophysiology, and experimental models.
  • Analysis of cellular and biochemical mechanisms implicated in COPD.
  • Integration of current knowledge on oxidative stress and lung microbiome in COPD.

Main Results:

  • Genetic factors significantly influence COPD development through various cellular and biochemical pathways.
  • Experimental models highlight the importance of oxidative stress and the lung microbiome in COPD.
  • Identified genetic targets demonstrate potential for therapeutic intervention and biomarker discovery.

Conclusions:

  • Genetic targets offer promising avenues for developing new treatments for COPD.
  • Genetic insights are crucial for identifying novel biomarkers in exhaled breath condensate for COPD.
  • Further research into genetic factors can lead to personalized medicine approaches for COPD management.