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Updated: Jan 22, 2026
03:22
Local Anesthetic Thoracoscopy for Undiagnosed Pleural Effusion
Published on: November 10, 2023
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[Diffuse infiltrative lung disease, pericarditis, pleural effusion and ceritinib hypersensitivity]
C-M Gaillard1, W Chumbi-Flores1, L Gaillot-Durand2
1Service de pneumologie, groupement hospitalier Nord, hospices civils de Lyon, 69317 Lyon cedex 04, France.
Revue Des Maladies Respiratoires
|July 9, 2019
Summary
Tyrosine kinase inhibitors like ceritinib can cause rare hypersensitivity reactions, including respiratory distress, pericarditis, and pleurisy, in patients with ROS1-positive lung cancer. This case highlights the need for careful monitoring of potential toxicities with these advanced therapies.
Area of Science:
- Oncology
- Pharmacology
Background:
- Tyrosine kinase inhibitors (TKIs) are crucial for treating ROS1-rearranged non-small-cell lung cancer.
- Rapid advancements in TKI therapies necessitate understanding their monitoring and toxicities.
Observation:
- A patient with metastatic lung adenocarcinoma and ROS1 rearrangement received ceritinib as third-line treatment.
- Within two months, the patient experienced acute respiratory distress, pericarditis, and pleurisy.
Findings:
- The patient's symptoms resolved within three days of discontinuing ceritinib and initiating corticosteroids, suggesting a hypersensitivity reaction.
- Pulmonary infiltration, pleural effusion, and pericarditis are uncommon toxicities associated with ceritinib.
Implications:
- This case underscores the importance of vigilance and regular monitoring for potential pulmonary toxicities when using ceritinib.
- Further research into the safety profile of ceritinib, particularly regarding hypersensitivity reactions, is warranted.
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