Implication of coumarins towards central nervous system disorders
Krystyna Skalicka-Woźniak1, Ilkay Erdogan Orhan2, Geoffrey A Cordell3
1Department of Pharmacognosy with Medicinal Plant Unit, Medical University of Lublin, 1 Chodzki Str., 20-093 Lublin, Poland.
Pharmacological Research
|December 15, 2015
Summary
Coumarins, plant-derived compounds, show significant central nervous system (CNS) effects. They hold promise for treating psychiatric and neurodegenerative disorders like Alzheimer's and depression.
Area of Science:
- Pharmacology
- Neuroscience
- Medicinal Chemistry
Background:
- Coumarins are prevalent plant-derived compounds with established pharmacological activities.
- Recent research highlights their significant impact on the central nervous system (CNS).
Purpose of the Study:
- To review the key pharmacological effects of natural and synthetic coumarins on the CNS.
- To explore their therapeutic potential for neurological and psychiatric conditions.
Main Methods:
- Literature review of studies on coumarin pharmacology.
- Analysis of structure-activity relationships for CNS effects.
- Examination of interactions with specific CNS targets.
Main Results:
- Coumarins interact with benzodiazepine receptors.
- They exhibit affinity for dopaminergic and serotonergic systems.
- Inhibition of cholinesterases and monoamine oxidases by coumarins was noted.
Conclusions:
- Coumarins demonstrate diverse CNS activities.
- Natural and synthetic coumarins show potential in treating psychiatric and neurodegenerative disorders.
- Further development for conditions like Alzheimer's, Parkinson's, anxiety, and depression is warranted.
Keywords:
Benzodiazepine receptorsCentral nervous systemCholinesterase inhibitorsCoumarinsMonoamine oxidase (MAO) inhibitorsγ-Aminobutyric acid (GABA)More Related Videos
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