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Body Mass Index Is Associated with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
Jie Dong1, Yi Chen2, Yuchen Tang3
1Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Plos One
|December 15, 2015
Summary
Patients with inflammatory bowel diseases (IBD), particularly Crohn's disease (CD), exhibit lower body mass index (BMI). Medical therapy did not significantly improve BMI in IBD patients, and disease activity impacts BMI.
Area of Science:
- Gastroenterology
- Clinical Nutrition
- Epidemiology
Background:
- Previous research indicates lower body mass index (BMI) in inflammatory bowel diseases (IBD) patients compared to controls.
- Lower BMI in IBD patients has been associated with more severe complications.
Purpose of the Study:
- To investigate the relationship between BMI in patients with and without IBD.
- To examine the effects of medical therapy and disease stages on patient BMI.
Main Methods:
- A systematic review and meta-analysis of studies from PubMed, Cochrane, and Embase databases.
- Pooled outcome measurements of mean BMI and patient numbers using a random-effect model.
- Conducted publication bias tests, sensitivity analyses, and subgroup analyses.
Main Results:
- Included 24 studies with 1442 IBD patients and 2059 controls.
- Crohn's disease (CD) patients had significantly lower BMI than healthy controls (mean difference -1.88).
- Active disease phases in both CD and ulcerative colitis (UC) patients showed greater BMI deficits compared to remission phases.
Conclusions:
- CD patients demonstrate lower BMI.
- Medical therapy did not demonstrate a significant improvement in BMI for IBD patients.
- Disease state, specifically active phase, significantly impacts BMI in both CD and UC patients.
