Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

MicroRNAs01:22

MicroRNAs

4.3K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.3K
MicroRNAs01:22

MicroRNAs

24.6K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.6K
MicroRNAs01:22

MicroRNAs

12.0K
12.0K
Abnormal Proliferation02:23

Abnormal Proliferation

5.4K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.4K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

5.1K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
5.1K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

10.2K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lesion Index-guided workflow for the treatment of paroxysmal atrial fibrillation is safe and effective - Final results from the LSI Workflow Study.

Heart rhythm O2·2022
Same author

OsSCL30 overexpression reduces the tolerance of rice seedlings to low temperature, drought and salt.

Scientific reports·2022
Same author

Biocompatible tellurium nanoneedles with long-term stable antibacterial activity for accelerated wound healing.

Materials today. Bio·2022
Same author

Time trends in cancer and dementia related hospital admissions among Medicare fee-for-service population, 2013-2018.

Journal of geriatric oncology·2022
Same author

Conducting molybdenum sulfide/graphene oxide/polyvinyl alcohol nanocomposite hydrogel for repairing spinal cord injury.

Journal of nanobiotechnology·2022
Same author

Changes in Refractive Error Under COVID-19: A 3-Year Follow-up Study.

Advances in therapy·2022

Related Experiment Video

Updated: Mar 28, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

504

microRNAs in the Malignant Transformation Process.

Anne E Sarver1, Lihua Li1, Reena V Kartha2

  • 1Department of Surgery, University of Minnesota, MMC 195, 11-211 Moos Tower, 515 Delaware Street, S.E., Minneapolis, MN, 55455, USA.

Advances in Experimental Medicine and Biology
|December 15, 2015
PubMed
Summary
This summary is machine-generated.

MicroRNAs regulate cancer progression from benign to malignant tumors. Understanding these microRNAs offers new therapeutic targets and diagnostic biomarkers for improved cancer treatment and patient outcomes.

Keywords:
Benign to malignant transformationBiomarkersColorectal cancerMalignant peripheral nerve sheath tumorPancreatic cancerProstate cancermicroRNA

More Related Videos

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR qPCR
08:30

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR qPCR

Published on: May 16, 2012

25.2K
Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

7.3K

Related Experiment Videos

Last Updated: Mar 28, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

504
MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR qPCR
08:30

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR qPCR

Published on: May 16, 2012

25.2K
Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

7.3K

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cancers often begin as benign neoplasms before becoming malignant.
  • Benign neoplasms do not invade tissues or metastasize.
  • The transition from benign to malignant is a crucial stage for effective cancer treatment.

Purpose of the Study:

  • To explore the role of microRNAs in the benign to malignant transformation.
  • To investigate this process in colorectal, pancreatic, malignant peripheral nerve sheath, and prostate cancers.

Main Methods:

  • Review of scientific literature on microRNA regulation in cancer progression.
  • Analysis of microRNA involvement in the specific cancer types mentioned.

Main Results:

  • MicroRNAs play critical roles in regulating the multistep progression of cancer.
  • Specific microRNAs are implicated in the transformation of benign neoplasms to malignant tumors in the selected cancers.

Conclusions:

  • Understanding microRNA-mediated regulation is key to identifying new therapeutic targets.
  • MicroRNAs can serve as diagnostic biomarkers for early cancer detection and improved patient outcomes.