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Dimeric Sesquiterpenoids.

Shang-Gao Liao1,2, Jian-Min Yue3

  • 1School of Pharmacy, Guizhou Medical University, Zhangjiang Hi-Tech Park, Shanghai, 201203, People's Republic of China. lshangg@163.com.

Progress in the Chemistry of Organic Natural Products
|December 15, 2015
PubMed
Summary
This summary is machine-generated.

Dimeric sesquiterpenoids (DSs), derived from two sesquiterpenoid units, show enhanced potency over monomers. These compounds exhibit diverse biological activities, including anti-tumor and anti-inflammatory effects, making them promising therapeutic agents.

Keywords:
Compound disesquiterpenoidsDimeric aza-sesquiterpenoidsDimeric sesquiterpenoidsDisesquiterpenoidsNuphar alkaloidsPseudo-disesquiterpenoids

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Area of Science:

  • Natural Product Chemistry
  • Medicinal Chemistry
  • Chemical Biology

Background:

  • Many proteins function as dimers or require dimerization for activation in cellular signaling.
  • Targeting both parts of dimeric proteins offers therapeutic potential.
  • Dimeric sesquiterpenoids (DSs) are natural products formed by coupling two sesquiterpenoid units.

Purpose of the Study:

  • To provide an overview of the classification and distribution of DSs.
  • To present strategies for structural elucidation of DSs and their analogues.
  • To review chemical strategies for synthesizing DSs and discuss their biological activities.

Main Methods:

  • Literature review on DS classification, distribution, and biological activities.
  • Summary of methods for structural elucidation of DSs.
  • Review of synthetic strategies for DS construction.

Main Results:

  • DSs are often more potent than their monomeric precursors in various activities.
  • Reported activities include anti-inflammatory, anti-tumor, immunosuppressive, potassium channel blocking, antimalarial, anti-viral, and neurotrophic effects.
  • The complex structures of DSs present challenges and opportunities for synthetic chemists.

Conclusions:

  • DSs represent a class of biologically active natural products with significant therapeutic potential.
  • Their unique dimeric structure allows for potent interactions with biological targets.
  • Further research into their synthesis and biological evaluation is warranted.