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Gastrointestinal polyposis syndromes.

M C Finan1, M K Ray

  • 1Emory University School of Medicine, Atlanta, Georgia.

Dermatologic Clinics
|July 1, 1989
PubMed
Summary
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This study reviews several cutaneointestinal syndromes characterized by colonic polyps, such as Gardner's syndrome and Peutz-Jeghers syndrome. It also highlights newly defined syndromes and ongoing research into acrochordons and polyps.

Area of Science:

  • Gastroenterology
  • Dermatology
  • Genetics

Background:

  • Cutaneointestinal syndromes often present with colonic polyps as a key feature.
  • Syndromes like Gardner's, Peutz-Jeghers, and Cronkhite-Canada are well-established examples.
  • Other conditions such as Cowden's disease, Muir-Torre syndrome, and neurofibromatosis also show increased polyp frequency.

Purpose of the Study:

  • To review recognized cutaneointestinal syndromes associated with colonic polyps.
  • To discuss newly defined syndromes in this category.
  • To address the controversial relationship between acrochordons and colonic polyps.

Main Methods:

  • Literature review of established and emerging cutaneointestinal syndromes.
  • Analysis of syndromic features, focusing on colonic polyps.

Related Experiment Videos

  • Discussion of current research and controversies.
  • Main Results:

    • Gardner's syndrome (familial adenomatous polyposis), Peutz-Jeghers syndrome, and Cronkhite-Canada syndrome are defined by colonic polyps.
    • Cowden's disease, Muir-Torre syndrome, and neurofibromatosis exhibit increased colonic polyp frequency.
    • Ruvalcaba-Myhre-Smith syndrome is identified as a new entity in this classification.

    Conclusions:

    • Several syndromes consistently feature colonic polyps.
    • The association of Ruvalcaba-Myhre-Smith syndrome with colonic polyps is newly recognized.
    • Further research is needed to clarify the link between acrochordons and colonic polyps.