Related Experiment Video
Updated: Mar 28, 2026
12:29
Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
Published on: May 30, 2011
14.3K
Interstudy repeatability of self-gated quantitative myocardial perfusion MRI
Devavrat Likhite1, Promporn Suksaranjit2, Ganesh Adluru1
1Utah Center for Advanced Imaging Research, Department of Radiology, University of Utah, Salt Lake City, Utah, USA.
Journal of Magnetic Resonance Imaging : JMRI
|December 15, 2015
Summary
This study found that self-gated, free-breathing cardiovascular magnetic resonance imaging shows good interstudy repeatability for myocardial blood flow (MBF) and myocardial perfusion reserve (MPR) in the near-systole phase. This technique offers comparable results to ECG-gated, breath-held methods.
Area of Science:
- Cardiovascular Magnetic Resonance Imaging
- Medical Imaging Physics
Background:
- Quantitative cardiovascular magnetic resonance (CMR) techniques assess myocardial blood flow (MBF) and myocardial perfusion reserve (MPR).
- Interstudy repeatability is crucial for reliable clinical application and longitudinal studies.
Purpose of the Study:
- To evaluate the interstudy repeatability of multislice quantitative cardiovascular magnetic resonance myocardial blood flow (MBF), myocardial perfusion reserve (MPR), and extracellular volume (ECV).
- To assess a unique saturation recovery self-gated acquisition for perfusion scans.
Main Methods:
- Ten subjects underwent ungated golden angle radial turboFLASH scans on a 3T scanner on two separate days.
- Images were reconstructed using iterative algorithms with spatiotemporal constraints and retrospectively self-gated into near-systole and near-diastole phases.
- Deformable registration accounted for respiratory and cardiac motion; Fermi modeling estimated MBF and MPR repeatability.
Main Results:
- The coefficient of variation (CoV) for territorial MPR was 18.6% using near-systole data, versus 46.2% for near-diastole data.
- For MBF, near-systole data yielded CoVs of 20.1% (stress) and 22.7% (rest), while near-diastole data showed CoVs of 48.6% (stress) and 44.9% (rest).
Conclusions:
- Self-gated, free-breathing CMR for MBF quantification demonstrates good interstudy repeatability in the near-systole phase.
- Results are comparable to established ECG-gated, breath-held techniques.
- Near-diastole data exhibited lower repeatability.
