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Men with Hypertension are More Likely to Have Severe Lower Urinary Tract Symptoms and Large Prostate Volume

Eu Chang Hwang1, Sun-Ouck Kim1, Deok-Hyun Nam1

  • 1Department of Urology, Chonnam National University Medical School, Gwangju, South Korea.

Lower Urinary Tract Symptoms
|December 15, 2015
PubMed

Insights

Men with hypertension often experience more severe lower urinary tract symptoms (LUTS) and larger prostates. This suggests a link between high blood pressure and LUTS in benign prostatic hyperplasia (BPH) patients.

Area of Science:

  • Urology
  • Cardiovascular Medicine
  • Gerontology

Background:

  • Lower urinary tract symptoms (LUTS) are common in men with benign prostatic hyperplasia (BPH).
  • A higher prevalence of cardiovascular disease is observed in patients with LUTS.
  • The relationship between LUTS and cardiovascular risk factors requires further investigation.

Purpose of the Study:

  • To evaluate the correlation between LUTS and cardiovascular risk factors in men with BPH.
  • To identify specific cardiovascular risk factors associated with LUTS severity and prostate characteristics.

Main Methods:

  • Retrospective review of medical records for 295 men undergoing transurethral resection of the prostate for BPH.
  • Assessment of cardiovascular risk factors including hypertension, diabetes mellitus (DM), smoking, and dyslipidemia.
  • Comparison of LUTS severity (International Prostatic Symptom Score - IPSS), prostate volume, PSA, Qmax, and PVR between groups with and without cardiovascular risk factors.

Main Results:

  • Men with hypertension showed significantly higher total IPSS and obstructive symptom scores compared to those without cardiovascular risk factors (P = 0.01 for both).
  • Systolic and diastolic blood pressure correlated positively with prostate volume (r=0.138, P=0.040; r=0.163, P=0.020) and IPSS-total (r=0.139, P=0.043; r=0.138, P=0.043).
  • No significant differences in LUTS or prostate parameters were found for men with DM, smoking, or dyslipidemia compared to controls.

Conclusions:

  • Hypertension is associated with increased LUTS severity and larger prostate volume in men with BPH.
  • These findings suggest a potential pathophysiological link between hypertension and LUTS.
  • Simultaneous management of comorbid hypertension and LUTS in BPH patients is recommended.
Abstract

Keywords:
hypertensionlower urinary tract symptomsprostatic hyperplasia

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