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Human Herpes Virus Type 6 and Febrile Convulsion

Mohammad Mehdi Houshmandi1, Alireza Moayedi2, Mohammad Bagher Rahmati3

  • 1.Pediatrician, Clinical Research Development Center of Children Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

Iranian Journal of Child Neurology
|December 15, 2015
PubMed

Insights

Human herpesvirus type 6 (HHV-6) infection was investigated in children with febrile convulsions (FC). While clinical signs were similar, HHV-6 infection was linked to prolonged postictal phases and seizures occurring within one hour of fever onset.

Area of Science:

  • Virology
  • Pediatrics
  • Infectious Diseases

Background:

  • Febrile convulsions (FC) are common in children aged 6 months to 5 years.
  • The role of human herpesvirus type 6 (HHV-6) in FC requires further investigation.

Purpose of the Study:

  • To determine the prevalence of HHV-6 infection in children admitted with FC.
  • To compare clinical manifestations and outcomes between HHV-6 infected and non-infected FC patients.

Main Methods:

  • A cross-sectional study involving 118 children (6-60 months) with FC.
  • Blood samples were collected at admission and 10 days post-admission for HHV-6 IgG detection via ELISA.
  • Statistical analysis (t-test, X2) was used to compare groups.

Main Results:

  • HHV-6 infection was detected in 23 out of 53 (43.4%) participants.
  • No significant differences in age, gender, or common clinical symptoms (rhinorrhea, diarrhea, vomiting, lethargy) were observed.
  • Prolonged postictal phase (>15 min) and seizures within 1 hour of fever onset were significantly more frequent in the HHV-6 infected group.

Conclusions:

  • HHV-6 infection prevalence in FC patients was 43.4% in this cohort.
  • While general clinical presentations did not differ, HHV-6 infection was associated with specific seizure characteristics.
  • These findings suggest HHV-6 may influence seizure duration and timing relative to fever onset in children.
Abstract

Keywords:
ChildrenFebrile convulsionHHV-6

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