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Peptic ulcers are erosive lesions of the gastric or duodenal lining, most commonly caused by Helicobacter pylori infection. This Gram-negative, helical bacterium has adapted to survive the stomach’s acidic environment by producing urease, which converts urea into ammonia and carbon dioxide. The ammonia neutralizes gastric acid in the bacterium’s immediate environment, allowing colonization of the gastric mucosa. H. pylori attaches to mucus-secreting epithelial cells, penetrates the...
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Pressure ulcers: treatment.

Madhuri Reddy1

  • 1Geriatric Medicine, University of California at San Francisco, San Francisco, California, US.

BMJ Clinical Evidence
|December 16, 2015
PubMed
Summary
This summary is machine-generated.

This systematic overview evaluated 15 treatments for pressure ulcers, common in immobile patients. It categorizes interventions by effectiveness and safety, aiding clinical decision-making for pressure ulcer management.

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Area of Science:

  • Clinical Medicine
  • Evidence-Based Practice
  • Dermatology

Background:

  • Pressure ulcers affect up to one-third of hospitalized individuals and one-fifth of nursing home residents.
  • Reduced mobility and poor skin condition increase pressure ulcer risk, particularly in older adults and those with vascular disease.

Purpose of the Study:

  • To systematically review the effects of various treatments for people with pressure ulcers.
  • To answer the clinical question: What are the effects of treatments in people with pressure ulcers?

Main Methods:

  • A systematic overview was conducted, searching major databases like Medline, Embase, and The Cochrane Library up to January 2014.
  • Searches retrieved 307 studies; 203 records were screened, and 40 full publications were evaluated.
  • A GRADE evaluation was performed for 15 PICO combinations.

Main Results:

  • Seven systematic reviews and two RCTs were added at this update.
  • Fifteen pressure ulcer interventions were evaluated for effectiveness and safety.
  • Data from 40 full articles were synthesized.

Conclusions:

  • The systematic overview categorized the efficacy of 15 interventions for pressure ulcer treatment.
  • Interventions included air-fluidised supports, debridement, dressings, and topical negative pressure.
  • Findings provide evidence for the effectiveness and safety of various pressure ulcer treatments.