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APOLIPOPROTEINS AND THEIR ASSOCIATION WITH CARDIOMETABOLIC RISK BIOMARKERS IN ADOLESCENTS
Mellina Neyla de Lima Albuquerque1, Alcides da Silva Diniz1, Ilma Kruze Grande de Arruda1
1Department of Nutrition. Federal University of Pernambuco, Recife, Brazil.. mellinaalbuquerque@yahoo.com.br.
Introduction:
the apoB/apo A-I ratio has been reported as an important predictor of cardiovascular risk, being superior to lipids, lipoproteins and conventional lipid ratios.
Objective:
to investigate the association between apolipoproteins A-I and B, and the apolipoprotein B/apolipoprotein A-I ratio and cardiometabolic risk variables in adolescents.
Methods:
this was a cross-sectional study including 104 adolescents of public schools in Recife during the months of March/April, 2013. Sociodemographic, anthropometric, clinical and biochemical variables were analysed. The apolipoproteins were analysed via Immunoturbidimetry.
Results:
body mass index, waist circumference, waist circumference/height, triglycerides, cholesterol/HDL, and apolipoprotein B/apolipoprotein A-I declined with the progress of the percentile distribution of apolipoprotein A-I concentrations, while the HDL and apolipoprotein B increased between the first and last quartiles of the apolipoprotein A-I concentrations. Systolic blood pressure, body mass index, waist circumference, waist circumference/height, cholesterol, LDL, triglycerides, cholesterol/HDL, and LDL/HDL increased progressively in the quartile distribution of the concentrations of apolipoprotein B and apolipoprotein B/apolipoprotein A-I. Alfa-1-acid glycoprotein serum levels increased hand-inhand with the percentile progression of apolipoprotein B.
Conclusions:
the findings underline an important association of apolipoproteins A-I and B, and the apolipoprotein B/apolipoprotein A-I ratio and their clinical, biochemical and anthropometric cardiometabolic risk. However, prospective studies are important to evaluate the pertinence of implementing these markers in the clinical practice.
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