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Related Concept Videos

Histology of the Small Intestine01:27

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The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
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The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
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The small intestine is primarily responsible for digestion and nutrient absorption. It spans from the pyloric sphincter to the ileocecal valve and connects to the large intestine.
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Related Experiment Video

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Establishment and Characterization of Small Bowel Neuroendocrine Tumor Spheroids
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SMALL INTESTINAL TUMORS.

V Bozhkov, R Magjov, P Chernopolsky

    Khirurgiia
    |December 17, 2015
    PubMed
    Summary
    This summary is machine-generated.

    Small intestinal tumors are rare, often diagnosed late due to vague symptoms. Surgical resection offers the only radical treatment for these gastrointestinal malignancies.

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    Area of Science:

    • Gastroenterology
    • Surgical Oncology
    • Oncology

    Background:

    • The small intestine constitutes 75% of the GI tract length and 90% of its mucosal surface.
    • Benign and malignant small intestinal tumors are infrequent, accounting for 3-6% and 1-3% of GI malignancies, respectively.

    Purpose of the Study:

    • To analyze the clinical presentation, diagnosis, and treatment outcomes of patients with small intestinal tumors.
    • To highlight the challenges in early diagnosis and the role of surgery in management.

    Main Methods:

    • Retrospective analysis of 23 patients diagnosed with small intestinal tumors between 2001 and 2014.
    • Diagnosis based on clinical presentation, performance status, and imaging (CT, MRI).
    • Surgical treatment involving tumor resection and anastomosis.

    Main Results:

    • Common presenting symptoms included bowel obstruction, abdominal pain, GI bleeding, and anemia.
    • Histological types comprised adenocarcinoma (56.5%), GIST (17.4%), sarcoma (9.3%), NET (8.7%), and lymphoma (8.1%).
    • All patients underwent surgical resection.

    Conclusions:

    • Small intestinal tumors are rare and frequently diagnosed at advanced stages due to nonspecific symptoms and diagnostic challenges.
    • Surgery is the primary modality for radical treatment.
    • Adjuvant chemotherapy is recommended for malignant small bowel tumors.