Adenoma detection with Endocuff colonoscopy versus conventional colonoscopy: a multicentre randomised controlled...

Area of Science:

• Gastroenterology
• Endoscopy
• Colorectal Cancer Screening

Background:

• Colonoscopy is the gold standard for detecting colorectal neoplasia.
• Adenoma detection rates (ADR) can be improved with enhanced visualization techniques.
• The Endocuff device is designed to improve colonic visualization during colonoscopy.

Purpose of the Study:

• To compare the adenoma detection rate (ADR) and mean number of adenomas per patient (MAP) between Endocuff-assisted colonoscopy (EAC) and conventional colonoscopy (CC).

Main Methods:

• A multicenter, randomized controlled trial was conducted with screening participants and symptomatic patients over 45 years old.
• Patients were randomized 1:1 to either EAC or CC, performed by experienced endoscopists.
• Colonoscopy quality indicators, including adenoma detection, were prospectively recorded.

Main Results:

• Endocuff-assisted colonoscopy (EAC) detected more adenomas overall (722 vs. 621).
• The mean number of adenomas per patient (MAP) was not significantly different between EAC and CC (1.36 vs. 1.17, p=0.08).
• The adenoma detection rate (ADR) was similar between groups (52% for both).

Conclusions:

• While Endocuff-assisted colonoscopy (EAC) may increase the total number of adenomas detected, it does not significantly increase the number of patients with at least one adenoma found.
• The clinical significance of increased adenoma detection with Endocuff regarding the reduction of interval colorectal cancers remains unknown.