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The Fungal Sexual Pheromone Sirenin Activates the Human CatSper Channel Complex

Shameem Sultana Syeda1, Erick J Carlson1, Melissa R Miller2,3

  • 1Department of Medicinal Chemistry and Institute for Therapeutics Discovery and Development, College of Pharmacy, University of Minnesota , Minneapolis, Minnesota 55414, United States.

ACS Chemical Biology
|December 18, 2015
PubMed
Summary

Researchers synthesized the fungal sex pheromone sirenin and demonstrated its ability to activate the CatSper channel in human sperm. This finding opens avenues for developing novel male contraceptives targeting sperm function.

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