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Updated: Jul 15, 2026

Metal-free Synthesis of Ynones from Acyl Chlorides and Potassium Alkynyltrifluoroborate Salts
09:58

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Published on: February 24, 2015

Syntheses of YCT-529: Net [3 + 2] Cycloaddition and One-Pot Bromination-Suzuki-Miyaura Coupling Strategies

Ravikrishna Dada1, Narsihmulu Cheryala1, Gunda I Georg1

  • 1Department of Medicinal Chemistry and Institute for Therapeutics Discovery and Development, University of Minnesota, 717 Delaware Street SE, Minneapolis, Minnesota 55414, United States.

The Journal of Organic Chemistry
|July 13, 2026
PubMed
Summary

Two synthetic routes were developed for YCT-529, a potential male contraceptive. These efficient, chromatography-free methods offer scalable options for future medicinal chemistry research and analog generation.

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