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Related Experiment Video

Updated: Mar 28, 2026

Creating a Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte to Study the Role of Cellular Architecture in Cardiomyocyte Systems Biology

Creating a Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte to Study the Role of Cellular Architecture in Cardiomyocyte Systems Biology

Published on: April 18, 2018

Modeling Fatty Acid Transfer from Artery to Cardiomyocyte.

Theo Arts¹, Robert S Reneman^2,3, James B Bassingthwaighte³

¹Department of Biomedical Engineering, CARIM, Maastricht University, Maastricht, the Netherlands.

Plos Computational Biology

|December 18, 2015

Summary

This summary is machine-generated.

Heart fatty acid (Fa) transfer to cardiomyocytes is crucial for energy. Our model shows Fa binding to carrier proteins, not membranes, limits transfer, offering new insights into cardiac energy metabolism.

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Last Updated: Mar 28, 2026

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Area of Science:

Cardiovascular Physiology
Biophysics
Cellular Metabolism

Background:

Long-chain fatty acids (Fa) are vital for cardiomyocyte contractile energy.
Mechanisms of Fa transfer from plasma to cardiomyocytes remain unclear.

Purpose of the Study:

To develop a novel model of Fa transfer dynamics.
To elucidate the rate-limiting steps in Fa uptake by cardiomyocytes.

Main Methods:

Physicochemical modeling of Fa diffusion and binding to carrier proteins (Cp).
Simulation of tracer dilution experiments in isolated rabbit hearts.
Comparison of model-predicted washout curves with experimental data.

Main Results:

Fa binding/release to Cp in aqueous zones, not cell membranes, hinders transfer.
Cell membranes are not a significant barrier to Fa diffusion.
Model simulations closely matched experimental washout curves.

Conclusions:

The developed model accurately represents Fa transfer in the heart.
Carrier protein interactions are the primary determinant of Fa uptake rate.
The model serves as a valuable tool for studying cardiac Fa metabolism.