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Updated: Aug 11, 2026

Human Skeletal Muscle Biopsy Procedures Using the Modified Bergström Technique
Published on: September 10, 2014
Long-term effects of altered activity on skeletal muscle
1Institute of Neurophysiology, University of Oslo, Norway.
Abstract:
This paper is a brief summary of some results obtained by stimulating denervated rat soleus (SOL) and extensor digitorum longus (EDL) muscles in vivo with different patterns of stimuli. It is concluded (1) that appropriate stimulation can maintain and restore normal properties in extrajunctional regions of denervated muscle; (2) that SOL and EDL respond differently to identical stimulation, indicating that the two muscles are intrinsically different; (3) that both frequency and amount of stimulation influence contractile properties but to varying degrees depending on the property and on the type of muscle under study; and (4) that the effects of stimulation on isometric and isotonic speed of shortening can be partly accounted for by its effect on excitation-contraction coupling processes and myosin heavy chain (MHC) expression.
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