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Updated: Mar 28, 2026

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
Published on: February 14, 2022
Double-lumen tubes and auto-PEEP during one-lung ventilation.
1Department of Anaesthesiology and Intensive Care Medicine, University Medical Center Freiburg, Hugstetter Str. 55, Freiburg 79106, Germany johannes.spaeth@uniklinik-freiburg.de.
Double-lumen tubes (DLTs) used in one-lung ventilation (OLV) contribute minimally to auto-positive end-expiratory pressure (auto-PEEP). DLT size and side do not significantly affect this auto-PEEP during thoracic anesthesia.
Area of Science:
- Anesthesiology
- Respiratory Physiology
- Thoracic Surgery
Background:
- Double-lumen tubes (DLTs) are essential for one-lung ventilation (OLV) in thoracic anesthesia.
- The narrow lumen of DLTs may increase resistance and contribute to auto-positive end-expiratory pressure (auto-PEEP).
Purpose of the Study:
- To investigate the impact of adult-sized DLTs on dynamic auto-PEEP during OLV.
- To quantify the DLT's contribution to auto-PEEP in patients undergoing thoracic surgery.
Main Methods:
- Prospective clinical study involving 72 patients undergoing thoracic surgery.
- Dynamic auto-PEEP was measured with various right- and left-sided DLTs.
- Air trapping was induced by altering the inspiration-to-expiration ratio to determine pressure gradients and auto-PEEP.
Main Results:
- The pressure gradient across the DLT (ΔPDLT) was 2.3 cm H2O.
- The mean total auto-PEEP was 2.9 cm H2O, with DLTs accounting for 27-31% of this value.
- DLT size and side did not significantly influence auto-PEEP levels.
Conclusions:
- DLTs contribute a small, clinically insignificant amount to overall auto-PEEP during OLV.
- The choice of DLT size or side does not meaningfully alter the risk of developing auto-PEEP.
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