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Potential Biomarkers Utilized to Define and Manage Overactive Bladder Syndrome
1Department of Urology, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan.
Lower Urinary Tract Symptoms
|December 18, 2015
Summary
Diagnosing overactive bladder (OAB) is challenging. New research explores urinary biomarkers and bladder wall thickness for objective diagnosis and treatment assessment, moving beyond subjective symptoms.
Area of Science:
- Urology
- Biomarker Research
- Diagnostic Tools
Background:
- Overactive bladder (OAB) diagnosis relies heavily on subjective symptoms, lacking objective measures.
- Current diagnostic methods like urodynamic studies are not universally applicable or fully definitive for OAB.
- There is a need for more objective, less invasive tools for OAB diagnosis and treatment monitoring.
Purpose of the Study:
- To review recent advancements in objective diagnostic and assessment tools for OAB.
- To explore the potential of urinary biomarkers and bladder wall thickness in OAB diagnosis.
- To discuss the limitations and future directions in OAB diagnostic strategies.
Main Methods:
- Review of current literature on OAB diagnostic biomarkers (urinary and serum).
- Analysis of studies investigating bladder wall thickness in OAB and related conditions.
- Exploration of multiplex biomarker assays for differential diagnosis.
Main Results:
- Urinary nerve growth factor (NGF) and prostaglandin E2 (PGE2) levels are elevated in OAB, decreasing with treatment.
- Single biomarkers show limited sensitivity; combined inflammatory biomarkers may improve differential diagnosis.
- Bladder wall thickness shows potential but lacks consistent conclusions for OAB diagnosis.
Conclusions:
- Objective diagnostic markers are crucial for improving OAB management.
- Investigating panels of urinary biomarkers offers promise for accurate OAB diagnosis and differentiation.
- Further research is needed to validate bladder wall thickness and novel biomarker panels for clinical use.
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