Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

New approach methodologies for evaluating developmental and reproductive toxicity potential: Review on state of the art, applicability for cosmetic related ingredients and coverage of developmental stages.

NAM journal·2026

Same author

NETest® 2.0-A decade of innovation in neuroendocrine tumor diagnostics.

Journal of neuroendocrinology·2025

Same author

Droplet Helical Motion on Twisted Fibers.

Langmuir : the ACS journal of surfaces and colloids·2024

Same author

Longitudinal profiling identifies co-occurring BRCA1/2 reversions, TP53BP1, RIF1 and PAXIP1 mutations in PARP inhibitor-resistant advanced breast cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2024

Same author

An exploration of testicular cancer survivors' experience of ejaculatory dysfunction following retroperitoneal lymph node dissection-a sub-study of the PREPARE clinical trial.

Journal of cancer survivorship : research and practice·2023

Same author

Advancing the use of new approach methodologies for assessing teratogenicity: Building a tiered approach.

Reproductive toxicology (Elmsford, N.Y.)·2023

Search research articles

Related Experiment Video

Updated: Mar 28, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

Prenatal Oxycodone Exposure Alters CNS Endothelin Receptor Expression in Neonatal Rats.

M Devarapalli¹, M Leonard¹, S Briyal¹

¹Department of Pediatrics, Divisions of Neonatology and Research, Advocate Children's Hospital and Department of Pharmaceutical Sciences, Chicago College of Pharmacy, Midwestern University, Downers Grove, USA.

|December 18, 2015

Summary

Prenatal oxycodone exposure in rats caused birth defects and altered brain endothelin-B (ETB) receptor expression, suggesting potential delays in central nervous system development.

More Related Videos

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes

Published on: February 28, 2025

Related Experiment Videos

Last Updated: Mar 28, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes

Published on: February 28, 2025

Area of Science:

Neuroscience
Developmental Biology
Pharmacology

Background:

Prenatal opioid exposure, including oxycodone, can negatively impact developing brains.
Endothelin (ET) receptors are crucial for normal central nervous system development and are implicated in opioid tolerance and withdrawal.
The precise mechanisms by which oxycodone affects the developing brain are not fully understood, but ET receptors are a potential pathway.

Purpose of the Study:

To investigate the impact of prenatal oxycodone exposure on brain endothelin ETA and ETB receptor expression during postnatal development in rats.
To determine if alterations in ET receptor expression correlate with observed adverse effects of prenatal oxycodone exposure.

Main Methods:

Timed pregnant Sprague-Dawley rats were administered oxycodone or placebo throughout gestation.
Male rat pups were collected on postnatal days 1, 7, 14, and 28.
Brain ETA and ETB receptor expression levels were quantified using Western blot analysis.

Main Results:

Oxycodone-exposed pups exhibited higher rates of congenital malformations and intrauterine growth retardation compared to controls.
On postnatal day 28, oxycodone-exposed pups had lower body and kidney weights.
ETA receptor expression was elevated on postnatal day 1 in the oxycodone group, while ETB receptor expression decreased on postnatal days 1 and 7, and increased on postnatal day 28.

Conclusions:

Prenatal oxycodone exposure leads to adverse outcomes including congenital malformations, growth retardation, and altered body/kidney weights.
The observed changes in ETB receptor expression in the brains of oxycodone-exposed rat pups suggest a potential disruption or delay in central nervous system development.