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Systems Medicine: Sketching the Landscape.
1Forschungszentrum Jülich GmbH, Projektträger Jülich, Molekulare Lebenswissenschaften, Jülich, 52425, Germany. m.kirschner@fz-juelich.de.
Methods in Molecular Biology (Clifton, N.J.)
|December 18, 2015
Summary
Systems Medicine, rooted in Systems Biology and systems-based thinking, offers a novel approach to managing clinical complexity. It represents an evolution, not a rebranding, of past medical practices.
Area of Science:
- Integrative biology and medicine
- Complexity science
- Health informatics
Background:
- Systems Medicine is often confused with related terms like precision medicine or big data medicine.
- Understanding its historical development is crucial to defining its unique concept.
- Its origins lie in Systems Biology, an integrative method for unraveling biocomplexity.
Purpose of the Study:
- To clarify the definition and concept of Systems Medicine.
- To differentiate Systems Medicine from other contemporary medical approaches.
- To highlight the historical trajectory and evolution of Systems Medicine.
Main Methods:
- Historical analysis of systems-based thinking.
- Tracing the development of Systems Biology.
- Examining the transition of Systems Biology into clinical practice.
Main Results:
- Systems Medicine is a distinct concept, not merely a rebranding of previous methods.
- Systems-based thinking, originating in ancient Greece, underpins both Systems Medicine and Systems Biology.
- Systems Biology has matured into an independent discipline capable of addressing biocomplexity.
Conclusions:
- Systems Medicine represents a genuine and novel approach to clinical complexity.
- The evolution from Systems Biology to Systems Medicine is paving the way for future medical practice.
- Understanding the foundational principles and developmental stages is key to the implementation of Systems Medicine.
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