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Biological processes as exploratory dynamics.

Jane Kondev1, Marc Kirschner2, Hernan G Garcia3

  • 1Department of Physics, Brandeis University, Waltham, Massachusetts.

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Summary
This summary is machine-generated.

Biological processes often use exploratory dynamics, involving repeated trials to reach a specific final state, unlike physics where initial conditions dictate outcomes. This approach ensures high-fidelity biological functions through trial-and-error mechanisms.

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Area of Science:

  • Biophysics
  • Cell Biology
  • Dynamical Systems Theory

Background:

  • Many biological processes achieve function through repeated, often abortive, dynamic trajectories.
  • Microtubule attachment to kinetochores exemplifies this, involving cycles of growth and shrinkage.
  • This contrasts with physical/chemical systems where initial conditions determine outcomes.

Purpose of the Study:

  • To propose 'exploratory dynamics' as a unifying concept for biological processes.
  • To investigate how systems achieve specific final states through random trajectories.
  • To analyze the fidelity and energetic costs of such dynamics.

Main Methods:

  • Review of historical principles of dynamics in physics and biology.
  • Comparison with biological phenomena exhibiting exploratory dynamics.
  • Quantitative modeling of exploratory dynamics using successive trial-and-error models.

Main Results:

  • Identified common features in biological processes relying on repeated trials to reach a 'winning' trajectory.
  • Explored how microscopic parameters influence exploratory dynamics.
  • Analyzed the energetic demands associated with these biological processes.

Conclusions:

  • Exploratory dynamics is a fundamental biological strategy for achieving high-fidelity functions when final states are critical.
  • This perspective offers a new framework for understanding diverse biological phenomena.
  • The study honors the legacy of Prof. Erich Sackmann's work on the dynamics of living organisms.