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Addressing corticosteroid insensitivity in adults with asthma
1a Institute of Infection, Immunity & Inflammation , University of Glasgow , Glasgow , UK.
Expert Review of Respiratory Medicine
|December 19, 2015
Summary
Corticosteroid insensitivity affects many with asthma. This review explores factors, molecular mechanisms, and future therapies to improve treatment response in asthma patients.
Area of Science:
- Pulmonology
- Genetics
- Pharmacology
Background:
- Corticosteroids are primary asthma treatments, but efficacy varies.
- Up to 33% of asthma patients exhibit corticosteroid insensitivity.
- Understanding insensitivity is crucial for effective asthma management.
Purpose of the Study:
- To review factors contributing to corticosteroid insensitivity in asthma.
- To explore molecular mechanisms underlying this insensitivity.
- To discuss current and future therapeutic strategies.
Main Methods:
- Literature review of genetic, environmental, and patient-related factors.
- Analysis of molecular pathways involved in corticosteroid resistance.
- Synthesis of information on therapeutic interventions and biomarkers.
Main Results:
- Identified genetic, environmental, demographic, and pharmacokinetic factors linked to insensitivity.
- Detailed molecular mechanisms including glucocorticoid receptor alterations and transcription factor activity.
- Highlighted potential therapies like small molecule drugs and biologics.
Conclusions:
- Corticosteroid insensitivity in asthma is multifactorial.
- Targeting molecular pathways offers therapeutic potential.
- Biomarkers may personalize treatment for corticosteroid-resistant asthma.
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