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Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

2.8K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
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Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

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Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
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Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Related Experiment Video

Updated: Sep 24, 2025

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System
06:07

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System

Published on: October 22, 2020

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Cigarette Smoking and Asthma.

Neil C Thomson1, Riccardo Polosa2, Don D Sin3

  • 1Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom.

The Journal of Allergy and Clinical Immunology. in Practice
|May 9, 2022
PubMed
Summary
This summary is machine-generated.

Half of adult asthma patients smoke. Smoking worsens asthma, creating unique challenges in diagnosis and treatment. More research including smokers is crucial for better asthma management.

Keywords:
AsthmaAsthma–chronic obstructive pulmonary disease overlapChronic obstructive pulmonary diseaseCigarette smokingSmokers with asthmaSmoking cessation

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Methods to Evaluate Cytotoxicity and Immunosuppression of Combustible Tobacco Product Preparations
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Area of Science:

  • Pulmonology and Respiratory Medicine
  • Clinical Medicine

Background:

  • Cigarette smoking affects approximately 50% of adult asthma patients, leading to a distinct asthma-smoking phenotype.
  • This phenotype complicates diagnosis, pathogenesis, and management, yet smokers are often excluded from research.
  • Understanding this interaction is vital for improving patient outcomes.

Approach:

  • This review synthesizes current knowledge on the clinical outcomes, diagnostic challenges, and pathogenic mechanisms of smoking in asthma.
  • It examines management strategies, including smoking cessation and adherence to Global Initiative for Asthma guidelines.
  • An evidence-based algorithm for managing smokers with asthma is proposed.

Key Points:

  • Smoking exacerbates asthma, causing airway inflammation, tissue remodeling, corticosteroid insensitivity, and systemic inflammation.
  • Diagnosing asthma in smokers with chronic respiratory symptoms, especially older individuals, presents significant challenges.
  • Effective management requires smoking cessation and tailored treatments, potentially targeting type 2 eosinophilic airway inflammation.

Conclusions:

  • There is a critical need for clinical trials that include adult smokers with asthma to develop evidence-based treatment recommendations.
  • The proposed management algorithm aims to assist clinicians in addressing the complexities of asthma in this population.
  • Further research is essential to improve the care and outcomes for individuals with asthma who smoke.