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Updated: Mar 28, 2026
07:29
Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
20.5K
[Cross-Linking in Keratoconus: "Epi-off" or "Epi-on"?].
F Raiskup1, V Veliká2, M Veselá2
1Klinik für Augenheilkunde, Universitätsklinikum Carl Gustav Carus, Dresden.
Klinische Monatsblatter Fur Augenheilkunde
|December 19, 2015
Summary
Corneal cross-linking (CXL) halts keratoconus progression. While "epi-off" CXL is most effective, less invasive "epi-on" methods are improving and gaining traction for keratoconus treatment.
Area of Science:
- Ophthalmology
- Biomedical Engineering
Context:
- Keratoconus is a progressive eye condition causing thinning and bulging of the cornea.
- Current treatments aim to halt disease progression and improve visual acuity.
- Corneal cross-linking (CXL) is a key therapeutic modality for managing keratoconus.
Purpose:
- To compare the efficacy of different corneal cross-linking (CXL) approaches for keratoconus.
- To evaluate the effectiveness of "epi-off" versus "epi-on" CXL in halting keratoconus progression.
- To assess the potential benefits and drawbacks of transepithelial CXL methods.
Summary:
- "Epi-off" CXL, involving epithelium removal, is currently the most effective method for strengthening the cornea and slowing keratoconus progression.
- "Epi-on" (transepithelial) CXL techniques aim to reduce patient discomfort and adverse events by preserving the corneal epithelium.
- While "epi-off" CXL demonstrates superior efficacy, ongoing research and development in "epi-on" methods show promising results and increasing adoption.
Impact:
- Provides evidence-based insights into optimal keratoconus management strategies.
- Informs clinical decision-making regarding the choice between "epi-off" and "epi-on" CXL.
- Highlights the evolving landscape of CXL techniques and their potential to improve patient outcomes in ophthalmology.
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