[Variation tendency in serum high density lipoprotein cholesterol and apolipoprotein A-I in different thyroid...

To study the metabolism of high density lipoprotein cholesterol (HDL-C) and apolipoprotein A-I (ApoA-I) in different thyroid function status during pregnancy.

This study recruited thirty cases of euthyroid, with nineteen cases of subclinical hypothyroid and eight cases of subclinical hyperthyroid pregnancy. The concentrations of fasting serum HDL-C and ApoA-I were detected and analyzed from 9-12, 14-17, 23-26, and 37-40 gestational weeks. Friedman repeated measures ANOVA on ranks was adopted to analyze the changes of serum HDL-C and ApoA-I at different stages. General linear model (GLM) was adopted to analyze the differences of serum HDL-C and ApoA-I in different thyroid function status during pregnancy.

There were no significant differences of maternal serum HDL-C among different stages (χ² = 5.428,P=0.143, χ² = 2.027,P=0.567, χ² = 2.885,P=0.410). There were significant differences of serum ApoA-I during euthyroid and subclinical hypothyroid pregnancies (χ² = 46.343, P<0.001, χ² = 35.984, P<0.001), and no significant difference during subclinical hyperthyroid pregnancy (χ² = 6.750, P=0.080). There were significant differences of serum HDL-C and ApoA-I between euthyroid and subclinical hyperthyroid pregnancies (P=0.025,P=0.027), and no significant differences between euthyroid and subclinical hypothyroid pregnancies (P=0.378,P=0.549).

Subclinical hyperthyroidism affected the metabolism of maternal serum HDL-C and ApoA-I, which could affect the fetal growth and development. Subclinical hypothyroidism (after treatment with drugs) had no obvious effect on the metabolism of maternal serum HDL-C and ApoA-I.