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Inhibition of the aspartic proteinase from HIV-2
A D Richards1, A V Broadhurst, A J Ritchie
1Dept of Biochemistry, University of Wales College of Cardiff.
FEBS Letters
|August 14, 1989
Abstract:
Kinetic constants were determined for the interaction of the HIV-2 aspartic proteinase with a synthetic substrate and a number of inhibitors at several pH values. Acetyl-pepstatin was more effective towards HIV-2 proteinase than the renin inhibitor, H-261; this effect is exactly the opposite from that observed previously for the proteinase from the HIV-1 AIDS virus.