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Updated: Mar 28, 2026
Experimental Model of Ligature-Induced Peri-Implantitis in Mice
Published on: May 17, 2024
No evidence for stopping long-term aspirin therapy before tooth extraction
Daphne Halley1, Robert Weld-Moore1, Brett Duane1
1Dublin Dental University Hospital, Dublin, Ireland.
Data Sources:
PubMed, ScienceDirect and EBSCOhost databases.
Study Selection:
Prospective randomised controlled trials (RCTs) or controlled trials.
Data Extraction And Synthesis:
Two independent investigators extracted data. The primary measured outcomes were rates of haemorrhage and bleeding time. Disagreements were clarified with a third investigator. Relevant authors were contacted if any relevant data was missing. The Grades of Recommendation, Assessment, Development and Evaluation (GRADE) system was used to evaluate the overall quality of evidence. The authors used standardised mean difference or relative risk to evaluate each outcome.
Results:
Ten studies were included, three randomised controlled trials and seven controlled trials. A total of 1752 patients were enrolled in the meta-analysis; the study group comprised 529 patients on long-term aspirin therapy, and the control group comprised 1223 patients. The risk of post-operative haemorrhage was significantly higher in patients on aspirin therapy (relative risk=2.46; 95% confidence interval: 1.45-4.81) but bleeding time was not significantly different between the two groups (standardised mean difference=0.63; 95% CI: - 0.04 to 1.31).
Conclusions:
Increased rates of haemorrhage are observed in patients on long-term aspirin therapy. The authors recommend not stopping long-term aspirin prior to dental extraction, and local measures for haemostasis should be enhanced when required.
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