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Diagnostic cordocentesis: two years of experience
1Department of Obstetrics & Gynecology, Hopital Erasme, Free University of Brussels, Belgium.
Summary
Diagnostic cordocentesis is a safe and reliable procedure for fetal assessment. This study reports a 2-year experience with 144 samplings, showing a low complication rate and providing valuable management guidelines.
Area of Science:
- Perinatal Medicine
- Fetal Diagnostics
Background:
- Cordocentesis, a fetal blood sampling technique, has evolved significantly.
- Early adoption of diagnostic cordocentesis in our unit began in October 1985.
Purpose of the Study:
- To report the initial 2-year experience with diagnostic cordocentesis.
- To evaluate the safety and reliability of the procedure.
Main Methods:
- 144 cordocentesis procedures were performed on 137 patients (139 fetuses) between 14 and 42 gestational weeks.
- Success rates, complications, and indications were recorded.
Main Results:
- 80% of procedures were successful on the first attempt; 4 samplings failed.
- No fetal deaths occurred within 3 days post-procedure.
- Transient fetal bradycardia (12.2%) and bleeding (13.6%) were the main complications.
Conclusions:
- Diagnostic cordocentesis is a safe and reliable procedure.
- The data provide guidelines for effective pregnancy management.
- Indications included fetal infection risk, karyotyping, hemophilia A, alloimmunization, paternity testing, and acid-base status assessment.