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Genetic predisposition of human plasma triglyceride concentrations
L Schwarzova1, J A Hubacek, M Vrablik
1Third Department of Internal Medicine, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic. lucie.schwarzova@yahoo.com.
Physiological Research
|December 19, 2015
Summary
High plasma triglyceride levels increase cardiovascular disease risk. Both environmental factors and genetic variations significantly influence these levels, impacting overall mortality.
Area of Science:
- Cardiovascular Medicine
- Genetics
- Metabolic Disorders
Background:
- Plasma triglyceride (TG) levels are a long-standing concern regarding cardiovascular disease (CVD) risk and overall mortality.
- TG levels are influenced by both environmental factors and genetic predispositions.
Purpose of the Study:
- To review the multifaceted factors influencing plasma triglyceride levels.
- To highlight the genetic underpinnings of plasma TG variations and their link to health outcomes.
Main Methods:
- Literature review and synthesis of existing research on plasma triglyceride determinants.
- Analysis of genetic factors, including rare mutations and common polymorphisms.
Main Results:
- Environmental influences such as diet, physical activity, and smoking significantly impact plasma TG.
- Rare mutations (e.g., in lipoprotein lipase, apolipoprotein C2) and common polymorphisms (e.g., in apolipoprotein A5, apolipoprotein E) are key genetic determinants of plasma TG levels.
Conclusions:
- Plasma triglyceride levels are critical indicators for cardiovascular health.
- Understanding the interplay of environmental and genetic factors is essential for managing TG levels and mitigating CVD risk.
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