A Case of Extraskeletal Ewing's Sarcoma Arising from Duodenum.

Area of Science:

• Oncology
• Gastroenterology
• Pathology

Background:

• Extraskeletal Ewing's sarcoma (EES) is a rare malignancy.
• Ewing's tumors encompass bone and soft tissue sarcomas with shared features.
• Gastrointestinal involvement of EES is exceptionally uncommon.

Purpose of the Study:

• To report the first documented case of extraskeletal Ewing's sarcoma arising from the duodenum.
• To describe the clinical presentation, diagnostic findings, and management of duodenal EES.
• To contribute to the understanding of rare gastrointestinal sarcomas.

Main Methods:

• Case report of a 14-year-old girl with hematemesis and epigastric discomfort.
• Diagnostic evaluation included duodenal biopsy with immunohistochemistry (MIC-2, vimentin, CD56).
• Treatment involved multiagent chemotherapy followed by surgical excision.

Main Results:

• Duodenal biopsy confirmed small round cell infiltration with positive MIC-2 (CD99), vimentin, and CD56 (NCAM).
• Initial partial response to chemotherapy was followed by rapid tumor progression.
• Surgical excision was performed due to disease progression.

Conclusions:

• This is the first reported case of extraskeletal Ewing's sarcoma originating in the duodenum.
• Duodenal EES presents diagnostic and therapeutic challenges.
• Further research is needed to establish optimal management strategies for this rare entity.