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Characteristics of Drug Resistance Mutations in a Korean HIV/AIDS Cohort, and Risk Factors for Resistance Acquisition
Minkyeong Lee1, Soo Min Kim2,3, Jun Hyoung Kim4
1Division of Infectious Diseases, Department of Internal Medicine, Ewha Womans University, College of Medicine, Ewha Womans University Mokdong Hospital, Seoul, Korea.
Abstract:
We aimed to characterize human immunodeficiency virus (HIV) drug-resistance mutations among patients in Korea HIV/acquired immunodeficiency syndrome (AIDS) Cohort. Among 1,579 surveyed between December 2006 and December 2020, 148 had resistance mutations (64 ART-naïve and 84 ART-experienced). The most common mutations in ART-naïve patients were related to non-nucleoside reverse transcriptase inhibitors (V179F/D/E/L; 50.0%), whereas those in ART-experienced were M184V/I (73.8%), conferring resistance to nucleotide reverse transcriptase inhibitors. Multivariate logistic regression identified poor compliance (adjusted odds ratio [aOR], 18.780; 95% confidence interval [CI], 1.883-187.300; P=0.012) and viral load ≥1-100,000 copies/mL at ART initiation (aOR, 3.117; 95% CI, 1.160-8.374; P=0.024) as being associated with resistance mutations.
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