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Acute generalized exanthematous pustulosis associated with ranolazine
Kurt Grelck1, Noelle Stewart2, Les Rosen3
1Forefront Dermatology, Stevens Points, Wisconsin, USA.
Cutis
|December 19, 2015
Summary
Acute generalized exanthematous pustulosis (AGEP) is a rare skin reaction often linked to medications. This case highlights ranolazine as a potential trigger for AGEP, emphasizing prompt drug withdrawal for resolution.
Area of Science:
- Dermatology
- Clinical Pharmacology
Background:
- Acute generalized exanthematous pustulosis (AGEP) is an uncommon but severe cutaneous adverse drug reaction.
- It is characterized by widespread erythema and numerous non-follicular pustules.
Observation:
- An 83-year-old male patient presented with symptoms suggestive of AGEP.
- The patient was administered ranolazine, an antianginal and anti-ischemic medication.
Findings:
- The case met the EuroSCAR criteria for definitive AGEP (score of 10/12).
- Discontinuation of ranolazine and treatment with oral prednisone led to the resolution of the rash and subsequent desquamation.
Implications:
- This case suggests ranolazine as a potential causative agent for AGEP.
- Awareness of this association is crucial for clinicians managing patients on ranolazine, particularly those with cardiac conditions.
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