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In Vivo Imaging of Transduction Efficiencies of Cardiac Targeting Peptide
Published on: June 11, 2020
A novel peptide adropin in cardiovascular diseases
Liang Li1, Wei Xie2, Xi-Long Zheng3
1Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, Medical Research Center, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, Hunan, China; Department of Pathophysiology, University of South China, Hengyang 421001, Hunan, China.
Insights
Adropin, a newly discovered peptide, shows potential in regulating cardiovascular functions and protecting against cardiovascular diseases like atherosclerosis and hypertension. Further research is needed to fully understand its mechanisms.
Area of Science:
- Cardiology
- Endocrinology
- Molecular Biology
Background:
- Cardiovascular diseases (atherosclerosis, hypertension) are leading global causes of death.
- Adropin, encoded by the Energy Homeostasis Associated gene, is a recently discovered peptide (2008).
- Adropin is expressed in various vital organs including the heart, liver, brain, and pancreas.
Purpose of the Study:
- To review current research on adropin's role in major cardiovascular diseases.
- To explore adropin's potential as a regulator of cardiovascular functions.
- To highlight adropin's protective role in cardiovascular disease pathogenesis.
Main Methods:
- Literature review of recent studies on adropin and cardiovascular diseases.
- Analysis of adropin expression patterns in different tissues.
- Synthesis of evidence regarding adropin's functional roles.
Main Results:
- Adropin is implicated in the regulation of cardiovascular functions.
- Evidence suggests adropin plays a protective role in cardiovascular disease development.
- Adropin's expression is widespread, including cardiac tissues.
Conclusions:
- Adropin emerges as a significant factor in cardiovascular health.
- The peptide demonstrates potential therapeutic relevance for cardiovascular diseases.
- Further investigation is crucial to elucidate the precise mechanisms of adropin's action in cardiovascular disease.
Abstract:
Cardiovascular diseases, such as atherosclerosis and hypertension, are the major cause of mortality and morbidity in the world. Adropin was first discovered in 2008 by Kumar and his coworkers. Adropin, encoded by the Energy Homeostasis Associated gene, is expressed in many tissues and organs, such as pancreatic tissue, liver, brain, kidney, endocardium, myocardium, and epicardium. In this review, we have summarized recent data suggesting the roles of adropin in several major cardiovascular diseases. Increasing evidence suggests that adropin is a potential regulator of cardiovascular functions and plays a protective role in the pathogenesis and development of cardiovascular diseases. However, further studies are needed to elucidate the specific mechanisms underlying the association between adropin and cardiovascular diseases.
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