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The burden of sexual dysfunction, including erectile dysfunction and premature ejaculation, is significant but understudied. It impacts patients economically and psychologically, affecting overall quality of life.

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Area of Science:

  • Sexual medicine
  • Public health
  • Health economics

Background:

  • Sexual dysfunction represents a significant health burden, comparable to other chronic diseases.
  • Evidence indicates diverse burdens, including economic, symptomatic, and humanistic impacts on affected individuals.
  • Research has predominantly focused on male sexual dysfunctions like erectile dysfunction (ED), premature ejaculation (PE), and testosterone deficiency syndrome (TDS).

Purpose of the Study:

  • To systematically review and highlight the underappreciated burden of sexual dysfunctions.
  • To underscore the economic, symptomatic, and humanistic consequences for patients and society.
  • To identify research gaps, particularly concerning female sexual dysfunction and paraphilic disorders.

Main Methods:

  • Systematic review of existing literature on the burden of sexual dysfunction.
  • Analysis of economic data, symptomatic impacts, and humanistic costs.
  • Identification and synthesis of studies focusing on ED, PE, TDS, and female sexual dysfunction.

Main Results:

  • Erectile dysfunction (ED) is linked to chronic conditions like cardiovascular disease and diabetes, potentially serving as an early diagnostic marker.
  • The UK estimated the economic burden of ED at £53 million annually, encompassing direct costs and lost productivity.
  • Premature ejaculation (PE) causes significant psychological distress, including anxiety, depression, and reduced quality of life; female sexual dysfunction may be associated with a partner's PE.
  • Testosterone deficiency syndrome (TDS) is associated with depression, cognitive impairment, and osteoporosis.
  • Economic burden estimates for female sexual dysfunctions in the UK exceeded those for ED per patient.
  • Data on the burden of paraphilic disorders remain scarce.

Conclusions:

  • The burden of sexual dysfunctions is substantial, affecting patients' quality of life and incurring significant societal costs.
  • Existing research is insufficient, particularly regarding female sexual dysfunction and paraphilic disorders.
  • Further systematic investigation is crucial to fully understand and address the multifaceted impact of sexual dysfunctions.