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Updated: Mar 28, 2026

Synthesis Method for Cellulose Nanofiber Biotemplated Palladium Composite Aerogels
Published on: May 9, 2019
Preparation, characterization and feasibility study of dialdehyde carboxymethyl cellulose as a novel crosslinking
Xiaolei Jiang1, Zhao Yang2, Yanfei Peng1
1Biochemistry Laboratory, College of Marine Life Sciences, Ocean University of China, No. 5 Yushan Road, Qingdao 266003, Shandong, PR China.
Abstract:
The natural biopolymers usually need to be chemically modified by crosslinking reagents to improve their mechanical properties. In the present research, the feasibility of using the dialdehyde carboxymethyl cellulose (DCMC) as a crosslinking reagent was systematically studied. DCMC was prepared by oxidizing carboxymethyl cellulose using sodium periodate. The formation of dialdehyde groups was confirmed by FTIR and the degree of oxidation was determined. The biocompatibility of DCMC was investigated by evaluating its cytotoxicity to L929 fibroblasts and histocompatibility in rat model via intramuscular and subcutaneous injection. DCMC-crosslinked carboxymethyl chitosan (DCMC-CMCTS) was prepared and characterized using the glutaraldehyde-crosslinked CMCTS (GA-CMCTS) as control. The result demonstrated that DCMC was non-cytotoxic, biodegradable and biocompatible. The DCMC-CMCTS displayed significantly better thermostability, swelling capacity and cyto-compatibility compared with GA-CMCTS. Our data provided experimental basis for the future application of DCMC as a novel crosslinking reagent.
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